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Retavase

Generic name: reteplaseRE-te-plase ]
Drug class: Thrombolytics

Medically reviewed by Drugs.com on Mar 18, 2024. Written by Cerner Multum.

What is Retavase?

Retavase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a "clot-busting" drug. It helps your body produce a substance that dissolves unwanted blood clots.

Retavase is used to improve heart function and prevent congestive heart failure or death in people who have had a heart attack (acute myocardial infarction).

Retavase may also be used for purposes not listed in this medication guide.

Retavase side effects

Get emergency medical help if you have signs of an allergic reaction: hives, rash, itching, skin redness; difficult breathing; swelling of your face, lips, tongue, or throat.

Retavase increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bleeding that will not stop. Bleeding may occur from a surgical incision, or from the skin where a needle was inserted during a blood test or while receiving injectable medication. You may also have bleeding on the inside of your body, such as in your stomach or intestines, kidneys or bladder, brain, or within the muscles.

Call your doctor at once if you have signs of bleeding inside your body, such as:

Also call your doctor at once if you have:

Common side effects may include nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

If possible before you receive Retavase, tell your doctor if you have a brain tumor or aneurysm, high blood pressure, hemophilia or other bleeding disorder, a history of stroke, or if you have recently had a head injury or surgery on your brain or spinal cord.

Before taking this medicine

You should not be treated with Retavase if you are allergic to it, or if you have:

If possible before you receive Retavase, tell your doctor if you have ever had:

In an emergency, you may not be able to tell caregivers about your health conditions. Make sure any doctor caring for you afterward knows you received Retavase.

If possible before you receive Retavase, tell your caregivers if you are pregnant or breastfeeding. Make sure any doctor caring for your pregnancy or your baby knows you received this medicine.

How is Retavase given?

Retavase is given as an infusion into a vein. A healthcare provider will give you this injection.

Retavase is usually given in two injections 30 minutes apart.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Retavase.

What happens if I miss a dose?

Because you will receive Retavase in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving Retavase?

Ask your doctor before taking aspirin or ibuprofen (Motrin, Advil) shortly after you have received Retavase. These medications can increase your risk of bleeding.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

What other drugs will affect Retavase?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect Retavase, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Does Retavase interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Retavase Biosimilars

Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.

Reference products

These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There is 1 for Retavase.

Retavase (reteplase) - Chiesi USA, Inc.
Formulation type Strength
Single-Dose Vial 10 units

Popular FAQ

Is Activase the same as tPA?

Yes, Activase is the same as tPA but technically tPA is an abbreviation for tissue plasminogen activator which is the drug class that encompasses all tissue plasminogen activators, of which there are 3 that have been FDA approved in the United States, namely Activase (generic name alteplase), Retavase (generic name reteplase), TNKase (generic name Tenecteplase). Sometimes healthcare professionals use "tPA" to refer to Activase because it was the first tissue plasminogen activator that was approved. But errors may arise because staff get confused between the abbreviation TNK and tPA, which has resulted in TNKase being given to a stroke patient instead of the intended Activase (TNKase is not approved for stroke patients).

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.